7,8 Dihydroxyflavone

"The Modern Nootropic"

7,8-Dihydroxyflavone (7,8-DHF) is a flavone found in many different plants. It was discovered in a search for molecules that imitate the function of brain-derived neurotrophic factor (BDNF). 7,8-Dihydroxyflavone acts as a nootropic that potentially improves brain health, mood, and cognitive function.

benefits

How

7,8 Dihydroxyflavone

can help you:

Studies in animals show that 7,8-DHF can aid with brain health in a plethora of ways. It is considered highly protective of the brain against various toxins/stressors in the modern world.

Longevity

  • Prevents neuronal cell death, remarkably even stronger than BDNF itself, which leads us to believe that this may prevent age-related cognitive decline and senescence (5).
  • 7,8-Dihydroxyflavone displays vasorelaxing and antihypertensive properties, thereby enhances blood flow, and combats lowers blood pressure (7).

Neuroprotective

  • Demonstrates a strong ability to protect dopamine neurons from cell death, thereby facilitates optimal brain function (6).
  • May play a pivotal role in recovery after traumatic brain injury, via TrkB signalling (8).
  • May prevent synaptic memory loss and deficits in synaptic plasticity (9).

Nootropic Properties

  • 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice (1).
  • 7,8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities, thereby exerting a potent protective qualities (2).
  • 7,8-Dihydroxyflavone is a BDNF receptor agonist, therefore is beneficial in neurogenesis, neuronal survival, neuroplasticity and resilience to low mood(3).
  • 7,8-Dihydroxyflavone promotes neurogenesis and exhibits Potent mood elevating effects (4).
DOSAGE STRATEGY

How to use

7,8 Dihydroxyflavone

As a dietary supplement, take 25mg of 7,8 DHF 1-2 times daily. It appears to be subject to extensive first-pass metabolism in the liver. Due to improved bioavailability, sublingual administration (under the tongue) may be preferred.

General population:

As a dietary supplement, take 25mg of 7,8 DHF 1-2 times daily. It appears to be subject to extensive first-pass metabolism in the liver. Due to improved bioavailability, sublingual administration (under the tongue) may be preferred.

Adults:

As a dietary supplement, take 25mg of 7,8 DHF 1-2 times daily. It appears to be subject to extensive first-pass metabolism in the liver. Due to improved bioavailability, sublingual administration (under the tongue) may be preferred.

25mg.
mg of

Ideal for:

Best used in acute situations.

Students, Executives, Brain performance.

CAUTIONS

7,8 Dihydroxyflavone

safety and
medication interactions.

Medication interactions

  • Blood Pressure medication.

Side Effects / Contraindications

  • Potential Photosensitivity.

Allergies

  • None known.

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Studies in animals show that 7,8-DHF can aid with brain health in a plethora of ways. It is considered highly protective of the brain against various toxins/stressors in the modern world.

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I am yet to trial 7,8 DHF, although I have heard only positive results. It appears to work rather quickly. Tolerance does build quickly though. Not unlike caffeine.

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Other Resources

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Scientific Citations